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KMID : 0812020060120010041
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Korean Journal of Neurogastroenterology and Motility
2006 Volume.12 No. 1 p.41 ~ p.47
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The Role of Pro- and Anti-inflammatory Cytokine Gene Polymorphisms in the Development of Post-infectious Irritable Bowel Syndrome
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Kim Hee-Sun
Park Hyo-Jin
Lim Jung-Hyun
Ji Sang-Won
Lee Sang-In
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Abstract
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Background/Aims: Bacterial gastroenteritis is known as a risk factor of irritable bowel syndrome (IBS). Mild inflammatory stimuli can perturb the sensory-motor system of the gut and contribute to symptoms associated with IBS. Thus, it is suspected that pro- and anti-inflammatory cytokine gene polymorphisms have an important role in the development of IBS. The aim of this study was to investigate the association of genetic polymorphisms of: tumor necrosis factor α (TNF-α), interleukin-10 (IL-10), and transforming growth factor-α1 (TGF-α1) with the development of postinfectious IBS (PI-IBS).
Methods: The subjects were recruited from our previous case-control study, where we investigated the incidence and risk factors of PI-IBS in patients with shigellosis during an outbreak. The presence of IBS and its subtypes were determined at 12 months after shigellosis infection using the Rome II criteria. In 13 patients with PI-IBS (group 1) with age- and sex-matched patients, 17, not having PI-IBS (group 2) and 20 normal controls (group 3), genotypes for TNF-α(-308*G/A), IL-10 (-1082*G/A) and TGF-α1 (+869*T/C, codon 10) were examined using the amplification refractory mutation system (ARMS) polymerase chain reaction (PCR).
Results: Allele frequencies and genotypes for TNF-α, IL-10, and TGF-α1 were found to have no significant differences among the three groups. Comparing two groups at a time, there were also no differences between groups.
Conclusions: Our findings suggest that genetic polymorphisms of TNF-α, IL-10, and TGF-α1 have no significant role in the development of PI-IBS. (Kor J Neurogastroenterol Motil 2006;12:41-47)
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KEYWORD
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Irritable bowel syndrome, Postinfectious irritable bowel syndrome
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